GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9815354 | 1 | rs6599179 | chr3:41855284 | ULK4 | chr3:41288091-42003660:- | 0.54 | 6.51 | 1.02E-9 | Diastolic blood pressure |
| UCEC | cis | rs4660306 | 1 | rs6667191 | chr1:45982844 | CCDC163P | chr1:45960581-45965646:- | -0.57 | -7.3 | 1.52E-11 | Homocysteine levels |
| UCEC | cis | rs9309473 | 1 | rs6705489 | chr2:73648811 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.51 | 1.5E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6707722 | chr2:73654363 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.13 | 7.16E-9 | Metabolite levels |
| UCEC | cis | rs60843830 | 1 | rs6709534 | chr2:217334 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.62 | 5.97E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9309473 | 1 | rs6710438 | chr2:73820108 | ALMS1P | chr2:73872046-73912692:+ | -0.47 | -5.47 | 1.81E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6711033 | chr2:73746643 | ALMS1P | chr2:73872046-73912692:+ | 0.45 | 5.3 | 3.96E-7 | Metabolite levels |
| UCEC | cis | rs11976180 | 1 | rs67239267 | chr7:143745116 | ARHGEF35 | chr7:143883677-143892736:- | -0.43 | -4.54 | 1.13E-5 | Obesity-related traits |
| UCEC | cis | rs9309473 | 1 | rs6724782 | chr2:73679990 | ALMS1P | chr2:73872046-73912692:+ | 0.57 | 6.81 | 2.1E-10 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6736866 | chr2:73661986 | ALMS1P | chr2:73872046-73912692:+ | 0.46 | 5.09 | 1.04E-6 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6740223 | chr2:73653332 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.13 | 7.16E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6745368 | chr2:73809974 | ALMS1P | chr2:73872046-73912692:+ | 0.48 | 5.61 | 9.18E-8 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6753344 | chr2:73653138 | ALMS1P | chr2:73872046-73912692:+ | -0.46 | -5.38 | 2.74E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6755217 | chr2:73641285 | ALMS1P | chr2:73872046-73912692:+ | 0.42 | 4.72 | 5.35E-6 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6755241 | chr2:73641364 | ALMS1P | chr2:73872046-73912692:+ | 0.45 | 5.16 | 7.55E-7 | Metabolite levels |